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Dapsone hypersensitivity syndrome with coexisting acute hepatitis E.

A Chogle1, A Nagral, A Soni

  • 1Kasturba Hospital for Infectious Diseases, Sane Guruji Marg, Mumbai.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
|May 17, 2000
PubMed
Summary
This summary is machine-generated.

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Dapsone hypersensitivity syndrome can cause fever, rash, and hepatitis. Steroid treatment resolved symptoms, suggesting a link between dapsone reactions and hepatitis E virus.

Area of Science:

  • Hepatology
  • Pharmacology
  • Immunology

Background:

  • Dapsone is a medication used to treat various conditions.
  • Hypersensitivity reactions to dapsone can manifest with diverse symptoms.
  • Hepatitis E virus (HEV) is a significant cause of acute viral hepatitis.

Observation:

  • A 14-year-old girl developed fever, lymphadenopathy, rash, and hepatitis after initiating dapsone therapy.
  • The patient's condition improved significantly upon dapsone discontinuation and initiation of prednisolone.
  • Hepatocellular injury was noted, alongside positive IgM anti-HEV antibodies.

Findings:

  • The clinical presentation and laboratory findings were consistent with dapsone hypersensitivity syndrome.
  • The co-occurrence of acute hepatitis E infection was identified.

Related Experiment Videos

  • Prednisolone therapy led to the reversal of all observed abnormalities.

    • Implications:

    • This case suggests a potential link between dapsone hypersensitivity syndrome and concurrent hepatotrophic viral infections like hepatitis E.
    • Clinicians should consider drug-induced hypersensitivity and viral hepatitis in patients presenting with similar symptoms.
    • Further research is warranted to explore the potential interaction between dapsone hypersensitivity and viral hepatitis.