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Genetic and environmental contributions.

M D Jensen1

  • 1Mayo Clinic, Rochester, MN 55905, USA.

Nutrition Reviews
|May 17, 2000
PubMed
Summary
This summary is machine-generated.

Insulin resistance shows significant variability, influenced equally by genetics and environment. Lifestyle changes like weight loss and exercise can greatly improve insulin sensitivity in affected individuals.

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Area of Science:

  • Metabolic Health
  • Human Physiology
  • Endocrinology

Background:

  • Insulin action exhibits considerable variability among individuals.
  • The insulin resistance syndrome is influenced by both genetic and environmental factors.
  • Environmental factors contribute approximately 50% to the development of insulin resistance.

Purpose of the Study:

  • To investigate the variability in human insulin action.
  • To delineate the contributions of inheritability and environmental influences on insulin resistance.
  • To assess the impact of lifestyle modifications on insulin sensitivity.

Main Methods:

  • Review of existing literature on insulin resistance and its determinants.
  • Analysis of studies reporting on the heritability and environmental influences on insulin action.

Related Experiment Videos

  • Examination of the effects of weight reduction and fitness training on insulin sensitivity.

    • Main Results:

    • Both familial (genetic) and environmental factors account for roughly 50% of the variation in insulin action.
    • Obesity and sedentary behavior are significant environmental contributors to insulin resistance.
    • Weight reduction and physical activity can substantially enhance insulin sensitivity.

    Conclusions:

    • Insulin resistance is a multifactorial condition with significant genetic and environmental components.
    • Lifestyle interventions are effective in improving insulin sensitivity.
    • Understanding the interplay between genetics, environment, and lifestyle is crucial for managing insulin resistance.