Related Experiment Video
Updated: Oct 16, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
Published on: April 7, 2021
Inspissated secretions: a life-threatening complication of prolonged noninvasive ventilation
K E Wood1, A L Flaten, W J Backes
1Respiratory Care Department and the Trauma and Life Support Center, University of Wisconsin Hospital and Clinics, Madison 53792, USA. kew@medicine.wisc.edu
Abstract:
Noninvasive Ventilation is frequently initiated in an attempt to avoid the complications of invasive mechanical ventilation. The optimal duration of this strategy is unclear, as prolonged noninvasive ventilation has associated complications. This case report illustrates the development of life-threatening inspissated secretions precipitating airway obstruction as a consequence of prolonged noninvasive ventilation.
Related Concept Videos
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive Positive-Pressure Ventilation (NIPPV)
Acute Respiratory Failure-III
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
Endotracheal Tube Extubation
Procedure
Extubation removes the endotracheal tube (ETT) from the patient on mechanical ventilation. It requires a well-coordinated, multidisciplinary approach involving physicians, nurses, respiratory therapists, and other healthcare professionals.