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The application of fluorescence in-situ hybridization to prenatal diagnosis
1Northwestern University Medical School, Prentice Women's Hospital and Maternity Center, Chicago, IL 60611, USA. epergame@nmh.org
Current Opinion in Obstetrics & Gynecology
|May 17, 2000
Abstract:
Fluorescence in-situ hybridization has become essential in prenatal diagnosis for identifying chromosome aberrations as well as in preimplantation genetic diagnosis and the analysis of fetal cells in maternal blood. Comparative genome hybridization, multicolor fluorescence in-situ hybridization and telomere probes provide technical approaches for the characterization of fetal chromosome anomalies not possible by conventional karyotyping.