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Investigations into a biomimetic approach toward CP-225,917 and CP-263,114
G A Sulikowski1, F Agnelli, R M Corbett
1Department of Chemistry, Texas A&M University, College Station, Texas 77842, USA.
The Journal of Organic Chemistry
|May 18, 2000
Abstract:
A biosynthesis of the structurally complex nonadride CP-225,917 (1) is outlined. A key step in this proposal is the dimerization of a C(16) anhydride derived from the condensation of lauric acid and oxaloacetic acid. An important element of this step is a templating effect imposed by two thioester linkages, reminiscent of a polyketide or fatty acid synthase pathway. On the basis of this principle, the dimerization of two C(11) anhydrides, templated by a 1,n-diol tether, leading to the core structure of CP-225,917 and CP-263,114 was investigated.