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Dematiaceous fungal keratitis. Clinical isolates and management
The British Journal of Ophthalmology
|July 1, 1975
Abstract:
Clinical and laboratory features of 16 cases of keratitis that were caused by dematiaceous pigmented fungi are reported. Management, including the treatment of nine cases with Natamycin (Pimaricin), resulted in corneal healing in 14 cases, and therapeutic surgery in two cases.
Insights
This study reports on 16 cases of keratitis caused by dematiaceous fungi. Treatment, including Natamycin, led to corneal healing in most patients, with surgery for severe cases.
Area of Science:
- Ophthalmology
- Mycology
- Infectious Diseases
Background:
- Keratitis, an inflammation of the cornea, can be caused by various pathogens, including fungi.
- Dematiaceous fungi, characterized by dark pigmentation, are an important group of fungal agents implicated in ocular infections.
Purpose of the Study:
- To describe the clinical and laboratory features of keratitis cases attributed to dematiaceous pigmented fungi.
- To evaluate the management strategies and outcomes for these fungal keratitis cases.
Main Methods:
- Retrospective analysis of 16 patients diagnosed with dematiaceous fungal keratitis.
- Review of clinical presentations, laboratory findings, and treatment regimens.
- Documentation of treatment outcomes, including corneal healing and need for surgical intervention.
Main Results:
- Sixteen cases of keratitis caused by dematiaceous pigmented fungi were identified.
- Nine patients were treated with Natamycin (Pimaricin).
- Corneal healing was achieved in 14 cases; two cases required therapeutic surgery.
Conclusions:
- Dematiaceous fungi are significant causative agents of keratitis.
- Prompt diagnosis and appropriate management, potentially including Natamycin, are crucial for successful outcomes.
- Surgical intervention may be necessary for refractory or severe cases.