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A versatile approach to PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 from L-(-)-quebrachitol
1Institute for Cognitive and Computational Science, Georgetown University Medical Center, Washington, DC 20007, USA.
Organic Letters
|May 18, 2000
Abstract:
[reaction: see text] A versatile synthesis of PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 is disclosed, starting from L-(-)-quebrachitol, a byproduct of latex production. The crystalline nature of most intermediates and the utilization of inexpensive protecting groups facilitate this synthetic route and its scale-up.