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Total synthesis of (-)-reveromycin B
A N Cuzzupe1, C A Hutton, M J Lilly
1School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia.
Organic Letters
|May 18, 2000
Abstract:
[structure: see text] The total synthesis of the epidermal growth factor inhibitor reveromycin B (2) is described. A novel, convergent, and stereoselective reaction sequence was utilized to construct the 5,6-spiroketal system 10 which was converted into the natural product 2 by a 16-step sequence.