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Novel one-step synthesis of thiazolo[3,2-b]1,2,4-triazoles
A R Katritzky1, A Pastor, M Voronkov
1Department of Chemistry, Center for Heterocyclic Compounds, University of Florida, Gainesville 32611-7200, USA. katritzky@chem.ufl.edu
Organic Letters
|May 18, 2000
Abstract:
[reaction: see text] Reactions of chalcones 3a-f with bis(1H-1,2,4-triazolyl) sulfoxide 4 formed the thiazolo[3,2-b]1,2,4-triazoles 5a-f, which resemble closely some previously prepared COX-2 inhibitors. The structure of 5a was confirmed by X-ray analysis.