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A method for the asymmetric hydrosilylation of N-aryl imines
1Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
Organic Letters
|May 18, 2000
Abstract:
[reaction: see text] The asymmetric reduction of N-aryl imines to yield chiral amines with enantiomeric excesses above 90% was achieved. Ethylenebis(eta5-tetrahydroindenyl)titanium difluoride ((EBTHI)TiF2, 1) was employed as the precatalyst with polymethylhydrosiloxane (PMHS) as the stoichiometric reducing agent. A variety of N-aryl imines derived from nonaromatic ketones were reduced with high ee.