Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polyamines: mysterious modulators of cellular functions.

K Igarashi1, K Kashiwagi

  • 1Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan. iga16077@p.chiba-u.ac.jp

Biochemical and Biophysical Research Communications
|May 18, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Excretion and uptake of putrescine by the PotE protein in Escherichia coli.

The Journal of biological chemistry·1997
Same author

Molecular mechanism of polyamine stimulation of the synthesis of oligopeptide-binding protein.

The Journal of biological chemistry·1997
Same author

Effects of bisphosphonates on alkaline phosphatase activity, mineralization, and prostaglandin E2 synthesis in the clonal osteoblast-like cell line MC3T3-E1.

Prostaglandins, leukotrienes, and essential fatty acids·1997
Same author

Inhibition of a medium chain acyl-CoA synthetase involved in glycine conjugation by carboxylic acids.

Biochemical pharmacology·1996
Same author

A second gene encoding a putative serine/threonine protein kinase which enhances spermine uptake in Saccharomyces cerevisiae.

Biochemical and biophysical research communications·1996
Same author

Histidine decarboxylase expression in mouse mast cell line P815 is induced by mouse peritoneal cavity incubation.

The Journal of biological chemistry·1996

Polyamines like putrescine, spermidine, and spermine are crucial for cellular functions. They modulate RNA, DNA, and protein synthesis by forming complexes, impacting cellular processes at a molecular level.

Area of Science:

  • Molecular Biology
  • Biochemistry

Background:

  • Polyamines (putrescine, spermidine, spermine) are essential cellular molecules.
  • Their functions are increasingly understood at the molecular level.
  • Polyamines interact with acidic biomolecules like RNA and DNA.

Purpose of the Study:

  • To elucidate the molecular mechanisms of polyamine functions.
  • To explain how polyamines modulate cellular processes.
  • To investigate the role of polyamines in RNA structure and protein synthesis.

Main Methods:

  • Molecular-level analysis of polyamine interactions.
  • Study of polyamine-RNA complexes under physiological conditions.
  • Investigation of polyamine effects on protein synthesis and ion channels.

Related Experiment Videos

Main Results:

  • Polyamines modulate RNA and DNA functions.
  • A significant portion of polyamine function is mediated by polyamine-RNA complexes.
  • Polyamines stimulate protein synthesis, ribosomal subunit assembly, and Ile-tRNA formation.
  • Polyamines influence ion channel activity.

Conclusions:

  • Polyamines play a critical role in regulating gene expression and protein synthesis.
  • The formation of polyamine-RNA complexes is central to their cellular functions.
  • Further research is clarifying polyamine effects on ion channels.