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Related Experiment Videos

Predicting conversion to Alzheimer disease using standardized clinical information.

E Daly1, D Zaitchik, M Copeland

  • 1Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Archives of Neurology
|May 18, 2000
PubMed
Summary

A standardized clinical assessment accurately predicts Alzheimer disease (AD) progression in individuals with questionable AD. The Total Box Score and specific interview questions identify those at high risk for developing probable AD.

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Area of Science:

  • Neurology
  • Gerontology
  • Clinical Assessment

Background:

  • Alzheimer disease (AD) diagnosis can be challenging in early stages.
  • Identifying individuals with "questionable" AD who are likely to progress is crucial for timely intervention.

Purpose of the Study:

  • To determine if a standardized clinical assessment can predict conversion to probable AD in individuals with "questionable" AD.
  • To identify specific predictors within the assessment for disease progression.

Main Methods:

  • A 3-year longitudinal study involving 165 individuals aged 65+.
  • Participants included those with normal cognition (CDR 0.0) and questionable AD (CDR 0.5).
  • Clinical Dementia Rating (CDR) Total Box Score and responses to 32 selected interview questions were analyzed.

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Main Results:

  • The CDR Total Box Score strongly predicted progression to probable AD.
  • Over 50% of individuals with a Total Box Score ≥2.0 progressed, versus ~10% with a Total Box Score ≤1.0.
  • Eight selected interview questions combined with the CDR Total Box Score accurately identified 88.6% of converters.

Conclusions:

  • A standardized clinical assessment effectively identifies individuals with questionable AD at high risk for progression.
  • The findings highlight the utility of the CDR Total Box Score and specific interview questions for predicting AD conversion.
  • Individual trajectories in questionable AD suggest diverse influencing factors warrant further investigation.