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Three families with polyneuropathy associated with monoclonal gammopathy
S M Manschot1, N C Notermans, L H van den Berg
1Department of Neuromuscular Disorders, Rudolf Magnus Institute of Neurosciences, Utrecht, The Netherlands.
Objective:
To report familial occurrence of polyneuropathy associated with monoclonal gammopathy.
Design:
Case reports.
Patients:
We describe 6 patients (3 pairs) with a polyneuropathy associated with IgM monoclonal gammopathy. Four of the 6 patients had a demyelinating polyneuropathy on neurophysiological examination. Three patients had elevated antibodies against myelin-associated glycoprotein. No duplication on chromosome 17 or a mutation on chromosome 1 was found in any family.
Conclusion:
Familial occurrence of polyneuropathy without the presence of hereditary motor and sensory neuropathy type I is a reason to search for the presence of monoclonal gammopathy.