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[Big differences in the frequency of polypharmacy between physicians].

L Bjerrum1, J Søgaard, J Hallas

  • 1Syddansk Universitet, Odense.

Ugeskrift for Laeger
|May 18, 2000
PubMed
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Major polypharmacy, defined as using five or more medications, varies significantly between general practices. Practice characteristics explain over half of this variation in prescribing multiple drugs.

Area of Science:

  • Pharmacology
  • Public Health
  • General Practice

Background:

  • Polypharmacy, the concurrent use of multiple medications, is linked to adverse drug events, medication errors, and hospitalizations.
  • Major polypharmacy (≥5 drugs) presents a significant patient risk, necessitating investigation into its prevalence and predictors.

Purpose of the Study:

  • To analyze the prevalence of major polypharmacy among patients registered in general practices.
  • To identify practice-related predictors associated with major polypharmacy.

Main Methods:

  • Utilized prescription data from the Odense Pharmaco-epidemiological Database for 173 general practices.
  • Calculated age- and sex-standardized prevalence rates of major polypharmacy per practice.
  • Employed backward stepwise linear multiple regression to identify predictors of major polypharmacy.

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Main Results:

  • A six-fold variation in major polypharmacy prevalence was observed across practices (16-96 per 1000 patients; median: 42).
  • Practice structure, workload, clinical work profile, and prescribing profile collectively explained 56% of the observed variation in major polypharmacy.

Conclusions:

  • Significant inter-practice variation exists in major polypharmacy prevalence.
  • Practice-level factors are important determinants of major polypharmacy, highlighting potential targets for intervention.