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Folate sufficient subjects do not accumulate additional folates during supplementation.

C R Santhosh-Kumar1, J S Bisping, S D Kick

  • 1Department of Medicine, Royal Hospital, Muscat, Oman.

American Journal of Hematology
|May 18, 2000
PubMed
Summary
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Folic acid supplementation did not raise blood folate levels in folate-sufficient alcoholic individuals. This finding enables objective determination of the recommended daily allowance (RDA) for folate.

Area of Science:

  • Nutritional Science
  • Clinical Trials
  • Biochemistry

Background:

  • Alcoholism is associated with altered folate metabolism.
  • Establishing folate sufficiency is crucial for nutritional recommendations.
  • Previous methods for assessing folate status were less precise.

Purpose of the Study:

  • To investigate the effect of folic acid supplementation on whole blood folate levels in alcoholic subjects.
  • To identify a threshold for folate sufficiency using objective measurements.
  • To inform the determination of a recommended daily allowance (RDA) for folate.

Main Methods:

  • Double-blinded, placebo-controlled trial.
  • Inclusion of 82 alcoholic subjects.
  • Quantification of whole blood folate levels using mass spectrometry.

Related Experiment Videos

Main Results:

  • Folic acid supplementation did not increase whole blood folate levels in subjects with baseline folate levels above the third quartile (folate sufficiency).
  • Mass spectrometry provided precise measurement of folate levels.
  • A clear distinction between folate-sufficient and insufficient states was established.

Conclusions:

  • Folate sufficiency in alcoholic individuals can be objectively identified.
  • The study provides a basis for determining a scientifically-backed RDA for folate.
  • Further research may refine folate recommendations for specific populations.