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Genetic control of cutaneous basophil hypersensitivity
The Journal of Experimental Medicine
|January 1, 1976
Summary
Contact hypersensitivity (CBH) and delayed hypersensitivity (DH) responses are elicited only in genetically capable responder guinea pigs. These immune responses are likely mediated by T cells, as defects are observed in nonresponder T cells.
Area of Science:
- Immunology
- Cellular immunology
- Hypersensitivity reactions
Background:
- Contact hypersensitivity (CBH) and delayed hypersensitivity (DH) are T-cell mediated immune responses.
- Genetic factors influence an individual's ability to mount these hypersensitivity reactions.
- Previous studies suggest a genetic basis for DNP-PLL responsiveness.
Purpose of the Study:
- To investigate the immunological basis of contact hypersensitivity (CBH) to DNP-GL.
- To determine the role of T cells and B cells in mediating CBH and DH responses.
- To explore the genetic control of hypersensitivity reactions.
Main Methods:
- Induction of CBH to DNP-GL in guinea pigs.
- Assessment of delayed type hypersensitivity (DH) to DNP-PLL.
- Comparison of immune responses between responder and nonresponder guinea pig populations.
Main Results:
- CBH to DNP-GL was observed exclusively in responder guinea pigs.
- Responder guinea pigs possess the genetic ability to develop DH to DNP-PLL.
- Nonresponder animals exhibited defects in T cells, not B cells, suggesting T-cell involvement.
Conclusions:
- CBH and DH are T-cell dependent immune responses.
- Genetic factors governing DH to DNP-PLL also control CBH to DNP-GL.
- T cells are crucial for mediating both CBH and DH.