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Related Experiment Videos

Infections and atherosclerosis.

M Leinonen1, P Saikku

  • 1Department in Oulu, KTL, National Public Health Institute, Finland. maija.leinonen@ktl.fi

Scandinavian Cardiovascular Journal : SCJ
|May 18, 2000
PubMed
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Infectious agents like Chlamydia pneumoniae may contribute to coronary heart disease (CHD). Research is ongoing to confirm if antibiotics could treat this inflammatory condition.

Area of Science:

  • Cardiovascular Science
  • Infectious Disease Epidemiology

Background:

  • Inflammation and infection were historically linked to atherosclerosis but this theory was largely abandoned.
  • Recent research revives the hypothesis that infectious agents may play a role in coronary heart disease (CHD).

Purpose of the Study:

  • To review the evidence linking infectious pathogens to atherosclerosis and CHD.
  • To explore the potential pathogenetic role of Chlamydia pneumoniae in CHD.

Main Methods:

  • Review of seroepidemiological studies associating pathogens with CHD.
  • Examination of evidence for pathogen presence in atherosclerotic lesions.
  • Consideration of animal studies and preliminary antibiotic intervention trials.

Main Results:

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  • Herpes viruses (CMV, HSV1), Helicobacter pylori, and Chlamydia pneumoniae are implicated in atherosclerosis.
  • The strongest evidence links the respiratory bacterium Chlamydia pneumoniae to CHD.
  • Preliminary studies suggest a potential pathogenetic role for C. pneumoniae.

Conclusions:

  • While a causal relationship is not yet proven, C. pneumoniae is a strong candidate for contributing to CHD.
  • Ongoing research and intervention trials may establish antimicrobial therapy for CHD treatment.