Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA-G in the human placenta: expression and potential functions.

P Le Bouteiller1

  • 1INSERM U 395, CHU Purpan, Toulouse, France.

Biochemical Society Transactions
|May 18, 2000
PubMed
Summary

Human Leukocyte Antigen-G (HLA-G) is found in the placenta, indicating a role in pregnancy. This study explores HLA-G

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Possible pathogenic role of the transmembrane isoform of CD160 NK lymphocyte receptor in paroxysmal nocturnal hemoglobinuria.

Current molecular medicine·2011
Same author

[Current debates on immunology of preeclampsia. Report of the sixth international workshop of Reunion Island (Indian Ocean, December 2008)].

Gynecologie, obstetrique & fertilite·2009
Same author

Human decidual NK cells: unique phenotype and functional properties -- a review.

Placenta·2006
Same author

Less HLA-G expression in Plasmodium falciparum-infected third trimester placentas is associated with more natural killer cells.

Placenta·2005
Same author

[The role of HLA-G expression in the embryo during implantation].

Journal de gynecologie, obstetrique et biologie de la reproduction·2004
Same author

[HLA-G and local placental immunity].

Gynecologie, obstetrique & fertilite·2003

Area of Science:

  • Immunology
  • Reproductive Biology
  • Molecular Biology

Background:

  • Human Leukocyte Antigen-G (HLA-G) is a non-classical MHC class I molecule.
  • It is uniquely expressed at the materno-foetal interface during pregnancy.

Purpose of the Study:

  • To describe the structural characteristics and placental expression of HLA-G.
  • To evaluate the in vitro functional properties of HLA-G in the context of pregnancy.

Main Methods:

  • Structural analysis of HLA-G.
  • Analysis of placental expression patterns.
  • In vitro functional assays to assess HLA-G properties.

Main Results:

  • HLA-G exhibits specific structural features.
  • Its expression is localized to the placenta.
  • Functional studies suggest roles in immune modulation and potentially non-immunological functions.

Conclusions:

  • HLA-G likely plays a crucial physiological role at the materno-foetal interface.
  • Potential functions include anti-viral activity and modulation of natural killer cell activity.
  • Further research is needed to fully elucidate its non-immunological functions during pregnancy.

Related Experiment Videos