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Published on: February 14, 2011
Do kinetics of the humoral response to Cryptococcus neoformans proteins during murine cryptococcosis reflect outcome?
S Neuville1, O Lortholary, F Dromer
1Unité de Mycologie, Institut Pasteur, Paris Cedex 15, France.
Infection and Immunity
|May 19, 2000
Abstract:
The kinetics of the humoral response to Cryptococcus neoformans proteins were studied in outbred mice infected with isolate NIH52D. Future nonsurvivors had earlier and stronger (i.e., more bands recognized) humoral responses than survivors. In addition, antibodies to a 56- to 60-kDa membrane antigen and to a 39- to 40-kDa cytosolic antigen were detected more frequently in samples from future nonsurvivors and from survivors, respectively (P < 0.05).

