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Updated: Aug 5, 2026
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Chronic Salmonella Infected Mouse Model
Published on: May 31, 2010
A functional cra gene is required for Salmonella enterica serovar typhimurium virulence in BALB/c mice
J H Allen1, M Utley, H van Den Bosch
1Department of Biochemistry, Microbiology, and Molecular Genetics, University of Rhode Island, Kingston, Rhode Island 02881, USA.
Infection and Immunity
|May 19, 2000
Abstract:
A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad(-), is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129-134, 1998). Here, evidence is presented that the mutation in SR-11 Fad(-) that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.
