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Related Experiment Videos

UV light and MSH receptors.

A K Chakraborty1, Y Funasaka, A Slominski

  • 1Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. sodi@biomed.med.yale.edu

Annals of the New York Academy of Sciences
|May 19, 2000
PubMed
Summary

Ultraviolet B (UVB) radiation increases skin pigmentation by boosting melanocyte-stimulating hormone (MSH) receptor production. This process, involving MSH and POMC peptides, protects skin from UVB damage and reduces cancer risk.

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Area of Science:

  • Dermatology
  • Molecular Biology
  • Photobiology

Background:

  • Ultraviolet B (UVB) radiation induces skin pigmentation, a protective response against further DNA damage and photocarcinogenesis.
  • The precise molecular mechanisms underlying UVB-induced pigmentation are not fully understood.
  • Previous research suggests a role for melanocyte-stimulating hormone (MSH) receptors in this process.

Purpose of the Study:

  • To elucidate the role of MSH receptors and POMC-derived peptides in UVB-induced cutaneous pigmentation.
  • To investigate the synergistic effects of UVB and MSH on melanin production.
  • To determine if UVB influences the expression of MSH receptors and POMC in human skin cells.

Main Methods:

  • Assessing MSH receptor activity and redistribution in response to UVB radiation in animal models (mice and guinea pigs).

Related Experiment Videos

  • Measuring melanin content in skin following UVB and MSH exposure.
  • Analyzing the expression of mRNAs for MSH receptors and POMC in human melanocytes and keratinocytes after UVB, MSH, or dbcAMP stimulation.

    • Main Results:

    • UVB radiation increases MSH receptor activity by redistributing receptors to the cell surface, enhancing cellular responsiveness to MSH.
    • UVB and MSH act synergistically to increase melanin content in animal skin.
    • UVB irradiation, MSH, and dbcAMP stimulate the production of mRNAs for MSH receptors and POMC in human melanocytes and keratinocytes.

    Conclusions:

    • UVB-induced skin pigmentation involves coordinated events where MSH receptors and POMC-derived peptides play a central role.
    • UVB enhances cutaneous pigmentation partly by increasing MSH receptor production and stimulating the synthesis of MSH and ACTH.
    • These findings support a model where MSH receptors and their ligands mediate the effects of UVB on melanogenesis.