Synthesis of 4-(n-hydroxy-n-methylamino)quinoline 1-oxide and its carcinogenic activity on mice

4-(N-Hydroxy-N-methylamino)quinoline 1-oxide (N-Me-4-HAQO), the structure of which consists of a quinoline 1-oxide moiety involved in carcinongenic 4-nitroquinoline 1-oxide and an N-hydroxy-N-methylamino group involved in N-hydroxy-N-monomethylaminoazobenzene, was sythesized and proved to be potently carcinogenic in mice by its subcutaneous injection.