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Linkage analysis of chromosome 2q in osteoarthritis
J Loughlin1, Z Mustafa, A Smith
1University of Oxford, Institute of Molecular Medicine, Oxford, UK.
Background:
In independent linkage studies chromosome 2q11-q24 and chromosome 2q23-35 have previously been implicated as regions potentially harbouring susceptibility loci for osteoarthritis (OA).
Objective:
To test chromosome 2q for linkage to idiopathic osteoarthritis.
Methods:
Using a cohort of 481 OA families that each contained at least one affected sibling pair with severe end-stage disease (ascertained by hip or knee joint replacement surgery), we conducted a linkage analysis of chromosome 2q using 16 polymorphic microsatellite markers at an average spacing of one marker every 8.5 cM.
Results:
Our results provide suggestive evidence for a locus at 2q31 with a maximum multipoint logarithm of the odds score (MLS) of 1.22 which increased to 2.19 in those families concordant for hip-only disease (n = 311). This suggestive linkage was greater in male-hip families (MLS = 1.57, n = 71) than in female-hip families (MLS = 0.71, n = 132).
Conclusions:
Chromosome 2q is likely to contain at least one susceptibility locus for OA.