Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lipoprotein modification and atherosclerosis in aging.

P D Reaven1, C Napoli, S Merat

  • 1Division of Endocrinology and Metabolism, Department of Medicine, Carl T. Hayden Veterans Administration Medical Center, Phoenix, AZ, USA.

Experimental Gerontology
|May 19, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ensuring safety requirement to home food and home restaurant: focus on a regional experience based on sector legislation, and future perspectives.

Annali di igiene : medicina preventiva e di comunita·2023
Same author

Inhibiting DNA methylation as a strategy to enhance adipose-derived stem cells differentiation: Focus on the role of Akt/mTOR and Wnt/β-catenin pathways on adipogenesis.

Frontiers in cell and developmental biology·2022
Same author

Implementation of a quality management system according to ISO 9001:2015 standards in an Angiology Unit: an Italian experience.

Annali di igiene : medicina preventiva e di comunita·2022
Same author

Hierarchical convolutional models for automatic pneu-monia diagnosis based on X-ray images: new strategies in public health.

Annali di igiene : medicina preventiva e di comunita·2021
Same author

Severe Acute Respiratory Infections (SARI) surveillance in over-65-years-old patients: the experience of a University hospital (seasons 2017-2018 and 2018-2019).

Annali di igiene : medicina preventiva e di comunita·2021
Same author

SARS-CoV-2 indoor contamination: considerations on anti-COVID-19 management of ventilation systems, and finishing materials in healthcare facilities.

Annali di igiene : medicina preventiva e di comunita·2020

Aging accelerates atherosclerosis by increasing lipoprotein modification through oxidative stress and other factors. Understanding these age-related changes is crucial for preventing cardiovascular disease in the elderly.

Area of Science:

  • Cardiovascular Science
  • Gerontology
  • Biochemistry

Background:

  • Atherosclerosis is a leading cause of death in the elderly.
  • Aging's impact on atherosclerosis development is understudied.
  • Lipoprotein modification is implicated in atherosclerosis.

Purpose of the Study:

  • To review how aging influences lipoprotein modification and atherosclerosis.
  • To explore age-related conditions that exacerbate vascular injury.
  • To highlight the need for further research into aging and atherosclerosis.

Main Methods:

  • Literature review of studies on aging, lipoprotein modification, and atherosclerosis.
  • Analysis of factors contributing to enhanced oxidative stress in aging.
  • Examination of age-associated conditions like hypertension, diabetes, and menopause.

Related Experiment Videos

Main Results:

  • Aging may enhance lipoprotein modification via oxidative stress, glycoxidation, and AGE formation.
  • Age-associated conditions (hypertension, diabetes, menopause) contribute to vascular injury.
  • Evidence suggests increased in vivo oxidative stress in older populations.

Conclusions:

  • Aging processes can promote atherosclerosis through enhanced lipoprotein modification.
  • Further research is needed to understand and mitigate age-related atherosclerosis.
  • Targeting lipoprotein modification may offer solutions for elderly cardiovascular health.