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Related Experiment Videos

Reflex excitability regulates prepulse inhibition.

E J Schicatano1, K R Peshori, R Gopalaswamy

  • 1Department of Psychology, Wilkes University, Wilkes-Barre, Pennsylvania 18766, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|May 20, 2000
PubMed
Summary
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Prepulse inhibition of reflexes depends on the reflex circuit's intrinsic excitability, not external processing. This study shows reflex modification reflects inherent circuit characteristics in rats and humans.

Area of Science:

  • Neuroscience
  • Neurophysiology
  • Behavioral Neuroscience

Background:

  • Prepulse stimuli typically decrease reflex amplitude, suggesting sensory processing modifies reflex circuits.
  • A common hypothesis is that prepulse processing, rather than intrinsic reflex circuit properties, dictates this modification.

Purpose of the Study:

  • To investigate whether the intrinsic characteristics of reflex circuits, not prepulse processing, determine prepulse modification of trigeminal and acoustic reflex blinks.
  • To test the hypothesis that reflex excitability dictates prepulse effects.

Main Methods:

  • Created rats with hyperexcitable trigeminal reflex blinks via unilateral substantia nigra pars compacta lesions (6-OHDA).
  • Compared prepulse modification of trigeminal and acoustic reflexes in control and lesioned rats.

Related Experiment Videos

  • Examined prepulse modification of trigeminal reflexes in humans with Parkinson's disease (hyperexcitable) and age-matched controls.

    • Main Results:

    • In control rats, acoustic prepulses inhibited both trigeminal and acoustic reflex blinks.
    • In 6-OHDA-lesioned rats, acoustic prepulses facilitated trigeminal blinks but inhibited acoustic blinks.
    • Prepulse modification magnitude correlated with reflex excitability in both rats and humans, including Parkinson's patients.

    Conclusions:

    • Reflex modification by prepulses is determined by the intrinsic excitability of the reflex circuit.
    • These findings challenge the notion that external sensory processing of the prepulse is the primary mechanism for reflex modification.
    • The study demonstrates a conserved principle of reflex modulation across species and conditions.