Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A beta vasoactivity in vivo.

Z Suo1, G Su, A Placzek

  • 1Roskamp Institute, Tampa, Florida 33613, USA. zsuo@com1.med.usf.edu

Annals of the New York Academy of Sciences
|May 20, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Clinical preliminary observation of RET inhibitors on tear fluid].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology·2025
Same author

Genetic parameters of vulva traits and impact of vulva scores on gilts culling in Large White pigs.

Animal : an international journal of animal bioscience·2025
Same author

Genetic parameters for bull effects on in vitro embryo production (IVP) and relationship between semen quality traits and IVP performance.

Animal reproduction science·2024
Same author

Cardiac MRI feature-tracking-derived torsion mechanics in systolic and diastolic dysfunction in systemic light-chain cardiac amyloidosis.

Clinical radiology·2024
Same author

Genetic association between the APOE ε4 allele, toxicant exposures and Gulf war illness diagnosis.

Environmental health : a global access science source·2023
Same author

Multibreed genomic prediction using summary statistics and a breed-origin-of-alleles approach.

Heredity·2023
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

Beta-amyloid (A beta) peptide causes cerebral vasoconstriction in vivo, potentially explaining reduced blood flow in early Alzheimer's disease (AD). This study investigated A beta's vasoactive properties in rats.

Area of Science:

  • Neuroscience
  • Vascular Biology
  • Pathophysiology

Background:

  • Alzheimer's disease (AD) is characterized by early hypoperfusion in the temporoparietal regions.
  • Beta-amyloid (A beta) peptide is a key factor in AD pathogenesis.
  • In vitro studies suggest A beta causes blood vessel constriction.

Purpose of the Study:

  • To investigate the in vivo vasoactive properties of A beta.
  • To determine if A beta directly affects cerebral blood flow and vascular resistance.

Main Methods:

  • Intra-arterial infusion of freshly solubilized A beta 1-40 in rats.
  • Monitoring of peripheral blood pressure, cerebral blood flow, and cerebrovascular resistance.

Main Results:

Related Experiment Videos

  • A beta infusion increased blood pressure in hypotensive rats only.
  • A beta specifically decreased cerebral cortex blood flow and increased vascular resistance.
  • No significant effects were observed in the heart or kidneys.

Conclusions:

  • A beta exhibits direct, specific vasoconstrictive effects on cerebral vessels in vivo.
  • This A beta-induced cerebral vasoconstriction may contribute to hypoperfusion in early Alzheimer's disease.