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Related Experiment Videos

Genomes and form. The case for teleomorphic recursivity.

R Von Sternberg1

  • 1Department of Invertebrate Zoology, Smithsonian Institution, Washington D.C. 20560, USA. Sternberg.Richard@nmnh.si.edu

Annals of the New York Academy of Sciences
|May 20, 2000
PubMed
Summary

The genotype-phenotype distinction is challenged by new data. Cellular systems, including proteins, can alter the genome, suggesting a dynamic interplay rather than a one-way street in evolution.

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Area of Science:

  • Evolutionary biology
  • Molecular genetics
  • Genomics

Background:

  • The genotype-phenotype distinction is a cornerstone of evolutionary theory.
  • Traditional views posit DNA as solely determining the phenotype, with no feedback.
  • This dogma is increasingly challenged by molecular genetics findings.

Purpose of the Study:

  • To review data demonstrating cellular systems' impact on the genome.
  • To explore how the phenotype can influence the genotype.
  • To introduce the concept of teleomorphic recursivity.

Main Methods:

  • Review of existing molecular genetics literature.
  • Analysis of protein-mediated effects on DNA and genome structure.
  • Conceptual framework development for genome-phenotype interactions.

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Main Results:

  • Proteins can induce mutations and modify DNA information heritably.
  • Cellular components like chromatin and metabolic pathways influence genome.
  • The concept of teleomorphic recursivity describes meaning transfer from form to genome.

Conclusions:

  • The genome-form partition is a formal distinction, not a material one.
  • Cellular structures play a crucial role in shaping the genome.
  • Evolutionary thinking must incorporate bidirectional genome-phenotype interactions.