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DNA release by line-1 (L1) retrotransposon. Could it be possible?
G Alves1, M T Kawamura, P Nascimento
1Divisão de Genética, Instituto Nacional de Câncer, Rio de Janeiro, Brazil. gbrown@inca.org.br
Annals of the New York Academy of Sciences
|May 20, 2000
Abstract:
We have verified the presence of line-1 retrotransposon (L1) in plasma DNA in 15/17 brain tumor (glioma) patients and in 6/6 healthy people by applying PCR amplification of part of the L1 5' end. The same samples were separately amplified for K-ras. Results suggested that L1 sequences are circulating throughout the body. We hypothesized the participation of transposable elements such as L1 in a putative DNA release mechanism.