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[Structure-functional states of liver mitochondrial membranes of rats exposed to irradiation]

N G Mironova1, V I Dreval', L V Sichevskaia

  • 1Kharkov State University, Ukraine.

Radiatsionnaia Biologiia, Radioecologiia
|May 20, 2000
PubMed

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...