[Clinico-immunological and allergological characteristics of population of the Middle ural]

Clinical investigation of immune and allergic state of 633 adult dwellers of the Middle Ural region was carried out. The first (occupational) group consisted of 479 workers of the industrial plant, most of which exposed to negative factors such as radiation, harmful chemical substances and stress. The second (control) group consisted of 154 town-dwellers, who did not work at the industrial plant. Immune state was assessed in 714 people. Clinical symptoms of immune deficiency were found in 67% of the occupational group and in 76% of the control group. Allergic condition and allergic-infection syndrome were common for both groups, the rate of infection syndrome being relatively low. The immune state of the occupational group showed in comparison to control reliable increase in absolute and relative amount of T-lymphocytes, in the ratio CD4+/CD8+ and in the level of serum IgG. It was found also the decrease in the concentration of T-killers, the amount of NK cells and B-lymphocytes, phagocyte activity and the level of serum IgA. It was suggested that regional and ecological peculiarities influence the immune state rather than induce clinical symptoms of immune deficiency.