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Identification of monozygotic twins that are concordant for preeclampsia
K M O'shaughnessy1, F Ferraro, B Fu
1Clinical Pharmacology Unit, Department of Medicine, University of Cambridge Clinical School, UK. km022@medschl.cam.ac.uk
American Journal of Obstetrics and Gynecology
|May 20, 2000
Abstract:
Preeclampsia is thought to be discordant in monozygotic twins. While recruiting for a genetic study into preeclampsia, we identified 4 sets of twins and a triplet gestation; all were monozygous on deoxyribonucleic acid "fingerprinting." Two twins were concordant for preeclampsia, and 2 of the triplets had pregnancy-induced hypertension, although only 1 of them had proteinuria. Hence we confirm the existence of monozygotic twins that are concordant for preeclampsia.