Related Experiment Video
Updated: Aug 13, 2026
11:22
Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
"Dem bones": osteochondral injuries of the knee
M H Hinshaw1, M J Tuite, A A De Smet
1Department of Radiology, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792-3252, USA.
Magnetic Resonance Imaging Clinics of North America
|May 20, 2000
Summary
Magnetic Resonance (MR) imaging is crucial for diagnosing and staging femorotibial joint osteochondral injuries. It helps identify bone contusions that may predict serious lesions and detects unstable osteochondral fragments, a treatable cause of knee pain.
Area of Science:
- Orthopedic imaging
- Radiology
- Biomedical engineering
Background:
- Osteochondral injuries of the femorotibial joint are a common cause of knee pain.
- Accurate diagnosis and staging are essential for effective treatment.
Purpose of the Study:
- To highlight the role of Magnetic Resonance (MR) imaging in the diagnosis and staging of osteochondral injuries.
- To discuss the predictive value of MR imaging characteristics for lesion progression.
- To emphasize MR imaging's utility in identifying unstable osteochondral fragments.
Main Methods:
- Review of current literature on MR imaging in osteochondral injuries.
- Analysis of MR imaging characteristics associated with different lesion types.
- Correlation of imaging findings with clinical outcomes.
Main Results:
- MR imaging is valuable for diagnosing and staging femorotibial osteochondral injuries.
- Specific bone contusion characteristics on MR imaging may predict progression to more severe lesions.
- MR imaging is vital for diagnosing occult fractures and classifying displaced intra-articular fractures.
- MR imaging is the best noninvasive test for assessing the stability of osteochondral fragments.
Conclusions:
- MR imaging is an indispensable tool for managing osteochondral injuries of the femorotibial joint.
- Identifying unstable osteochondral fragments with MR imaging facilitates timely and effective treatment, addressing a key cause of knee pain.
Related Concept Videos
01:27Growth of Cartilage and Bone Tissue
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
01:27Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:16Bones of the Lower Limb: Femur and Patella
The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the neck...
01:23Knee Joint
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...
01:24Bone Formation by Endochondral Ossification
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...