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Malignant phyllodes tumor with liposarcomatous components: a case report with cytological presentation
T Satou1, N Matsunami, C Fujiki
1Second Department of Pathology, Kinki University School of Medicine, Osakasayama, Osaka, Japan. takaosat@med.kindai.ac.jp
Diagnostic Cytopathology
|May 23, 2000
Summary
This study presents a rare malignant phyllodes tumor of the breast with liposarcomatous components. Key cytological findings, including atypical stromal cells and lipoblasts, aid in diagnosing this challenging breast tumor.
Area of Science:
- Oncology
- Cytopathology
- Surgical Pathology
Background:
- Phyllodes tumors of the breast are rare fibroepithelial neoplasms.
- Malignant phyllodes tumors require accurate diagnosis for appropriate management.
- Liposarcomatous differentiation is an uncommon finding in phyllodes tumors.
Observation:
- A breast lesion initially suspected as benign based on clinical and imaging findings.
- Preoperative fine-needle aspiration smears showed low cellularity but stromal cell atypia and naked nuclei.
- Excisional biopsy revealed a malignant phyllodes tumor with liposarcomatous components.
Findings:
- Cytological imprint smears demonstrated peculiar atypical cells with clear cytoplasm and intranuclear inclusions.
- Atypical lipoblasts were identified, indicating liposarcomatous differentiation.
- Histological examination confirmed the diagnosis of malignant phyllodes tumor with liposarcomatous elements.
Implications:
- Definitive cytological diagnosis of rare malignant phyllodes tumors is possible with recognition of specific cellular features.
- Accurate cytopathological identification of atypical cells and lipoblasts is crucial.
- Long-term patient surveillance for recurrence and metastasis is essential after surgical management of this rare breast tumor.