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A cytotoxic diterpene from Alomia myriadenia
C L Zani1, T M Alves, R Queiróz
1Laboratório de Química de Produtos Naturais, Centro de Pesquisas René Rachou-FIOCRUZ, Belo Horizonte, MG, Brazil.
Phytochemistry
|May 23, 2000
Abstract:
An extract of the aerial parts from Alomia myriadenia Schultz-Bip. ex Baker (Asteraceae) showed significant cytotoxicity against a panel of human cancer cell lines in a screening of extracts from Brazilian Atlantic Forest plant species. Employing a bioassay-linked HPLC-electrospray/MS method, followed by semi-preparative HPLC, the active component was isolated and characterized as a mixture of epimers of the labdane diterpene 12S,16-dihydroxy-ent-labda-7,13-dien-15,16-olide.