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Retinoblastomas in Ibadan Nigeria: II--Clinicopathologic features
E E Akang1, I A Ajaiyeoba, O B Campbell
1Department of Pathology, University College Hospital, Ibadan, Nigeria.
West African Journal of Medicine
|May 23, 2000
Summary
This study on retinoblastoma in Nigerian children found a later diagnosis age compared to Caucasian children. Leukocoria was the most common sign, with significant optic nerve involvement and metastasis.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Pathology
Background:
- Retinoblastoma is a primary malignant intraocular neoplasm in children.
- Understanding its clinicopathological features is crucial for early diagnosis and treatment.
Purpose of the Study:
- To review the clinicopathological features of retinoblastoma in Ibadan, Nigeria.
- To compare findings with international data.
Main Methods:
- Analysis of clinical, surgical pathology, and histological data.
- Review of 44 histologically verified retinoblastoma cases from the University of Ibadan Cancer Registry.
Main Results:
- Retinoblastomas constituted 1.1% of childhood malignancies.
- Mean age at diagnosis was 32.3 months, older than in Caucasian children.
- Leukocoria was the most frequent clinical sign; 18% had bilateral disease.
- Optic nerve involvement was observed in 78% of cases.
- Metastasis occurred in regional lymph nodes and other sites.
Conclusions:
- Retinoblastoma in Ibadan, Nigeria, presents later than in Caucasian populations.
- Leukocoria is a key indicator, and optic nerve involvement is common.
- Further research into risk factors and outcomes in this population is warranted.