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06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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Hypothalamic-pituitary dysfunction associated with Moyamoya disease in children
S L Mootha1, W J Riley, P G Brosnan
1University of Texas Health Science Center, Houston 77030, USA.
Summary
Moyamoya disease, a rare cerebrovascular condition, can affect children
Area of Science:
- Neurology
- Pediatrics
- Endocrinology
Background:
- Moyamoya disease involves progressive narrowing of the circle of Willis arteries, leading to compensatory collateral vessel formation.
- It most commonly affects children, often presenting with transient ischemic attacks.
Observation:
- Two pediatric cases of Moyamoya disease with concurrent hypothalamic-pituitary dysfunction are presented.
- Both children sought endocrinology evaluation due to diminished growth velocity.
Findings:
- One child exhibited hypothyroidism.
- Both children were diagnosed with growth hormone deficiency.
Implications:
- This suggests a potential link between Moyamoya disease and hypothalamic-pituitary dysfunction.
- Close monitoring for endocrine abnormalities is recommended in children with compromised cerebral perfusion.
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