Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Blood coagulation.

B Dahlbäck1

  • 1Department of Clinical Chemistry, Lund University, University Hospital, Malmö, Sweden. bjorn.dahlback@klkemi.mas.lu.se

Lancet (London, England)
|May 23, 2000
PubMed
Summary
This summary is machine-generated.

The coagulation system maintains a balance favoring anticoagulation. Understanding vitamin K antagonists, heparin, and gene therapy offers insights into managing clotting disorders and deficiencies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel insights into the regulation of coagulation by factor V isoforms, tissue factor pathway inhibitorα, and protein S.

Journal of thrombosis and haemostasis : JTH·2017
Same author

The association between apolipoprotein M and insulin resistance varies with country of birth.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2014
Same author

Bacterial activity at the air/water interface.

Microbial ecology·2013
Same author

Resistance to activated protein C due to a factor V gene mutation The most common inherited risk factor of thrombosis.

Trends in cardiovascular medicine·2011
Same author

Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood.

Journal of thrombosis and haemostasis : JTH·2010
Same author

The role of phospholipid transfer protein in lipoprotein-mediated neutralization of the procoagulant effect of anionic liposomes.

Journal of thrombosis and haemostasis : JTH·2010
Same journal

Inherited retinal degenerations: clinical phenotypes and emerging therapies.

Lancet (London, England)·2026
Same journal

Documenting hospice care.

Lancet (London, England)·2026
Same journal

After the wood chipper.

Lancet (London, England)·2026
Same journal

Assisted dying and the silencing of medicine's next generation.

Lancet (London, England)·2026
Same journal

Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

Lancet (London, England)·2026
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
See all related articles

Area of Science:

  • Biochemistry
  • Hematology
  • Molecular Biology

Background:

  • The coagulation system normally favors anticoagulation.
  • Thrombin is a central enzyme in the clotting cascade.
  • Vitamin K-dependent modifications are crucial for coagulation protein function.

Purpose of the Study:

  • To review the balance of the coagulation system.
  • To discuss mechanisms of anticoagulation.
  • To explore therapeutic options for coagulation disorders.

Main Methods:

  • Review of coagulation cascade and regulatory mechanisms.
  • Discussion of vitamin K antagonists and heparin.
  • Analysis of knockout mouse models for coagulation factors.
  • Consideration of gene therapy for inherited deficiencies.

Related Experiment Videos

Main Results:

  • Vitamin K antagonists interfere with protein modification.
  • Heparin enhances antithrombin activity.
  • Knockout mice reveal the in vivo importance of coagulation factors.
  • Gene therapy shows promise for factor VIII and IX deficiencies.

Conclusions:

  • The coagulation system is tightly regulated.
  • Pharmacological agents like vitamin K antagonists and heparin modulate coagulation.
  • Genetic approaches, such as gene therapy, offer future therapeutic potential for inherited bleeding disorders.