Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ossicular chain reconstruction using a new tissue adhesive.

J L Maw1, J M Kartush

  • 1Michigan Ear Institute, Farmington Hills, USA.

The American Journal of Otology
|May 23, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Smoking and tympanoplasty: implications for prognosis and the Middle Ear Risk Index (MERI).

The Laryngoscope·2002
Same author

Implications of sound levels generated by otologic devices.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2001
Same author

Tympanic membrane Patcher: a new device to close tympanic membrane perforations in an office setting.

The American journal of otology·2000
Same author

Tympanic membrane perforation repair using AlloDerm.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2000
Same author

Octylcyanoacrylate: a new medical-grade adhesive for otologic surgery.

The American journal of otology·2000
Same author

Intra-operative monitoring in acoustic neuroma surgery.

Neurological research·1998

New octylcyanoacrylate tissue adhesive significantly improved hearing outcomes in rat ossicular chain reconstruction. The medical-grade adhesive demonstrated no significant histotoxicity, offering a promising solution for otologic surgery.

Area of Science:

  • Otolaryngology
  • Biomaterials Science
  • Surgical Innovation

Background:

  • Otologists require an ideal tissue adhesive for reconstructive procedures.
  • Previous cyanoacrylates showed inconsistent efficacy and toxicity.
  • Octylcyanoacrylate presents as a novel tissue adhesive with favorable properties for otologic applications.

Purpose of the Study:

  • To evaluate the efficacy of a new medical-grade cyanoacrylate tissue adhesive in improving ossicular chain reconstruction outcomes.
  • To assess the histotoxicity of octylcyanoacrylate in a rat model.

Main Methods:

  • Ossicular chain reconstruction was performed in 13 rats, with the incus interposed using octylcyanoacrylate in the adhesive group (n=7) and without adhesive in the control group (n=6).
  • Pre- and postoperative auditory brainstem response (ABR) testing was conducted.

Related Experiment Videos

  • Histopathologic analysis of temporal bones was performed at 8 weeks.

    • Main Results:

    • The adhesive group showed significantly better postoperative air conduction ABR results (34.3 dB vs. 62.5 dB, p=0.010) and air-bone gaps (18.9 dB vs. 47.5 dB, p=0.008).
    • Ossicular chain integrity was maintained in 100% of the surviving adhesive group rats compared to 50% in the control group.
    • Mild foreign body reaction was noted around the ossicular chain in the adhesive group, with no other significant histopathologic differences.

    Conclusions:

    • Octylcyanoacrylate significantly enhances hearing results in ossicular chain reconstruction.
    • The new adhesive demonstrates a favorable safety profile with no apparent histotoxicity in this animal model.
    • This medical-grade tissue adhesive represents a promising advancement for otologic surgical procedures.