Behavioral effect of mouse fibrinopeptide A on mouse forced swimming
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Updated: Oct 16, 2026
The Mouse Forced Swim Test
Published on: January 29, 2012
Y Masuda1, Y Kawarada, T Sugiyama
1Psychosomatic Division, Akita University School of Medicine, Hondo 1-1-1, 010-8543, Akita, Japan.
Abstract:
A specific dopamine 2 receptor antagonist, (-)sulpiride, induced an anti-depressive behavior, climbing, in mice forced to swim for 6 h after the injection. The effective fraction was divided from the mouse serum using an ion exchanger and an ultra filtration method. This fraction contained fibrinopeptide A. A peptide synthesized according to the primary 6-amino acid sequence (TDTEDK) of fibrinopeptide A also remarkably increased the behavior. The present findings clearly indicate that a peptide with TDTEDK showed anti-depressive activity.
