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Subcellular ontogeny of brain pyroglutamyl peptidase I
J M De Gandarias1, J Irazusta, J Gil
1Department of Physiology, Medical School, University of the Basque Country, Leioa, P.O. Box 699, Bilbao, Spain.
Peptides
|May 24, 2000
Abstract:
The present work studies pyroglutamyl-peptidase I activity in several subcellular fractions of the developing brain. In the synaptosomal fraction, soluble pGlu-peptidase I activity is low until postnatal Day 9 (with a peak at postnatal Day 2) and the activity increases at postnatal Day 15. In later stages there are not significant changes of synaptosomal pGlu-peptidase I activity. However, in the cytosolic fraction the activity is high from ED22 until postnatal Day 9, and afterwards decreases. The changes in the particulate fractions are generally less drastic.