Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple antibiotic sensitivity syndrome in children.

J Park1, D Matsui, M J Rieder

  • 1Children's Hospital of Western Ontario, London, Canada.

The Canadian Journal of Clinical Pharmacology = Journal Canadien De Pharmacologie Clinique
|May 24, 2000
PubMed
Summary

Pediatric multiple antibiotic sensitivity syndrome (MASS) involves immunologically mediated adverse drug reactions to various antibiotic classes. Further research is needed to define MASS as a distinct clinical entity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression.

Genes, brain, and behavior·2018
Same author

Relationship between Cnm-positive Streptococcus mutans and cerebral microbleeds in humans.

Oral diseases·2015
Same author

Pharmacokinetics of arginine butyrate in patients with hemoglobinopathy.

Environmental toxicology and pharmacology·2011
Same author

Canadian directions for enhancing drug discovery and investigation in children: A brighter future.

Paediatrics & child health·2010
Same author

British and Canadian views on the ethics of paediatric clinical trials.

European journal of clinical pharmacology·2007
Same author

Measurement of dijet azimuthal decorrelations at central rapidities in pp collisions at sqrt s =1.96 TeV.

Physical review letters·2005

Area of Science:

  • Pediatric Pharmacology
  • Clinical Immunology
  • Adverse Drug Reactions

Background:

  • Multiple antibiotic sensitivity syndrome (MASS) is documented in adults but poorly characterized in children.
  • Adverse drug reactions to multiple antibiotic classes present unique challenges in pediatric care.

Purpose of the Study:

  • To determine the prevalence of adverse drug reactions to multiple antibiotic classes in children.
  • To characterize the clinical presentation and patterns of these reactions in a pediatric population.

Main Methods:

  • Retrospective chart review of children referred to a specialized adverse drug reaction clinic.
  • Analysis of 97 pediatric patient records with suspected reactions to multiple antibiotics.

Main Results:

Related Experiment Videos

  • Reactions to two to five antibiotic classes were observed in all studied children.
  • Penicillins, cephalosporins, and sulfonamides were the most frequent triggers.
  • Common clinical manifestations included urticaria, rashes, and angioedema.

Conclusions:

  • Children can experience immunologically mediated adverse drug reactions to multiple antibiotic classes.
  • The clinical presentation often involves skin manifestations and follows specific drug use patterns.
  • Further investigation is required to establish MASS as a distinct pediatric syndrome and understand its underlying mechanisms.