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[Lupus anticoagulant: complete automation (ACL-Futura) and diagnostic algorithm]
C Aulesa1, J Tusell, J J Ortega
1Laboratorio de Hematología del Hospital Universitario Materno-Infantil del Vall d'Hebrón, Barcelona.
Purpose:
The technical and clinical evaluation of a new laboratory profile with six tests, for the realization of the assay called "lupic anticoagulant" with the help of ACL-Futura analyzer (Intrumentation Laboratory).
Results:
The within-between day imprecision of the tests that compose the profile: APTT-Diluted, APTT-D Mix, LacScreen, LacScreen Mix, LacConfirm and LacConfirm Mix, are between 2.87%-11.61% with controls, this imprecision is lowest with patients. A study of bilirrubin and lipemia interferences is presented. The practicability study present the technical, time consuming difficulty, and shows that the cost of the screening test is about 1136 ptas (6.83 euros) and with the confirmative test is 2766 ptas (16.62 euros). The clinical study describes our preliminary results with the application of this new profile for almost 2 years and six clinical cases are presented.
Conclusions:
The good technical and clinical results of the evaluation of the new profile proposed to detect the positive lupic anticoagulant, in addition to the fully automated assay with the ACL-Futura analyzer, validate the whole method to resolve the increased demand of these parameters.