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Novel bioadhesive delivery system for percutaneous local anaesthesia
D F McCafferty1, A D Woolfson, G P Moss
1School of Pharmacy, Queen's University of Belfast, UK.
British Journal of Anaesthesia
|May 24, 2000
Summary
A new bioadhesive amethocaine patch offers effective local anesthesia, comparable to amethocaine gel. This novel patch provides a more defined dosage form for percutaneous local anesthesia.
Area of Science:
- Dermatology
- Pharmacology
- Anesthesiology
Background:
- Percutaneous local anesthesia is crucial for minor dermatological procedures.
- Amethocaine gel (Ametop) is an established formulation for topical anesthesia.
- Novel drug delivery systems aim to improve efficacy and patient compliance.
Purpose of the Study:
- To evaluate the efficacy of a novel bioadhesive amethocaine patch.
- To compare the anesthetic properties of the amethocaine patch with amethocaine gel.
- To assess the onset and duration of action for percutaneous local anesthesia.
Main Methods:
- A randomized, double-blinded trial was conducted with 30 volunteers.
- Amethocaine patch, amethocaine gel, and placebos were applied to the forearm for 40 minutes.
- Anesthesia was assessed via pinprick testing, with pain scores recorded for 4 hours post-application.
Main Results:
- Both amethocaine gel and patch formulations demonstrated superiority over placebo (P < 0.05).
- No statistically significant difference was found between the amethocaine gel and patch in terms of onset or duration of anesthesia (P > 0.05).
Conclusions:
- The novel bioadhesive amethocaine patch provides clinically comparable local anesthesia to the established gel formulation.
- The patch offers a more defined dosage form for delivering percutaneous local anesthesia.
- This study supports the use of the bioadhesive patch as an effective alternative for topical anesthesia.