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Yeasts and fluconazole susceptibility in the Philippines

G S Bulmer1, M L Marquez, L Co-Barcelona

  • 1University of Santo Tomas School of Medicine & Surgery, Department of Laboratory Medicine, Manila, Philippines. Glenn@compass.com.ph

Mycopathologia
|May 24, 2000
PubMed

Insights

A study of 579 yeast isolates in the Philippines found that most were susceptible to fluconazole. Candida albicans, the most common yeast, showed high susceptibility to this antifungal medication.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Yeasts are a significant cause of opportunistic infections in healthcare settings.
  • Antifungal susceptibility testing is crucial for guiding treatment decisions.
  • Fluconazole is a widely used antifungal agent.

Purpose of the Study:

  • To identify yeast species isolated from patients in the Philippines.
  • To determine the in vitro susceptibility of these yeast isolates to fluconazole.

Main Methods:

  • Isolation and speciation of 579 yeast samples from 16 medical centers.
  • Agar disk diffusion assay was employed to assess fluconazole susceptibility.

Main Results:

  • Candida albicans was the most prevalent species (49.6%).
  • 94% of all yeast isolates were susceptible to fluconazole, with only 1% resistant.
  • All Candida albicans isolates demonstrated susceptibility to fluconazole.

Conclusions:

  • The majority of clinical yeast isolates in the Philippines are susceptible to fluconazole.
  • Fluconazole remains an effective treatment option for common yeast infections in the region.
  • Monitoring antifungal resistance patterns is essential for public health.

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