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Updated: Aug 12, 2026

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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
A general route to 4-imidazolyl-containing multidentate ligands for biomimetic studies
1Department of Chemistry, Stanford University, California 94305-5080, USA. jpc@chem.stanford.edu
Organic Letters
|May 24, 2000
Abstract:
[formula: see text] 4-iodo-1-tritylimidazole undergoes magnesium-iodine exchange with a Grignard reagent to give selectively the 4-magnesioimidazole derivative, which reacts with esters to form a variety of poly-4-imidazolyl carbinol compounds in 40-79% yields. A wide range of bi-, tri-, and pentadentate ligands featuring 4-substituted imidazole units have been efficiently synthesized.
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