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Short step enantioselective synthesis of (-)-swainsonine
T Punniyamurthy1, R Irie, T Katsuki
1Department of Molecular Chemistry, Graduate School of Science, Kyushu University, Fukuoka, Japan.
Chirality
|May 29, 2000
Abstract:
Recent discovery of asymmetric desymmetrization of meso-heterocycles using (R,R)-(salen)manganese complex 2 as a catalyst allowed easy access to optically active 2,3,4-trisubstituted pyrrolidines. Taking advantage of this new reaction, we could achieve the short-step synthesis of (-)-swainsonine 1.