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Optical rotation per refractive index unit, or enantiomeric (e) factor, for screening enantioselective catalysts
R Angelaud1, Y Matsumoto, T Korenaga
1Tokyo Institute of Technology, Tokyo, Japan.
Chirality
|May 29, 2000
Abstract:
A super high-throughput screening (SHTS) system can be constructed by combining high-performance liquid chromatography (HPLC), optical rotation (OR), and refractive index unit (RIU) to determine not only the enantioselectivity of the addition of diethylzinc to an aliphatic aldehyde catalyzed by a binaphthol-zinc complex through asymmetric activation with chiral Schiff bases, but also the enantiopurity of a carbohydrate. The enantiomeric (e) factor, which we define here as optical rotation per refractive index unit, is linearly related to the percent enantiomeric excess (%ee) and is independent of concentration.