Related Experiment Video

Updated: May 5, 2026

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury
07:03

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury

Published on: February 15, 2022

1.3K

Spontaneous bacterial peritonitis induced by intraarterial vasopressin therapy

S Bar-Meir, H O Conn

    Gastroenterology
    |March 1, 1976
    PubMed

    Insights

    Vasopressin infusions for gastrointestinal bleeding can lead to spontaneous bacterial peritonitis. This condition, caused by arterial vasoconstriction, allows gut bacteria to migrate into the abdominal cavity.

    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Vascular Medicine

    Background:

    • Upper gastrointestinal hemorrhage is a critical condition often managed with arterial infusions.
    • Vasopressin is a vasoconstrictor used to control bleeding by reducing blood flow.
    • Spontaneous bacterial peritonitis (SBP) is typically associated with liver disease and ascites.

    Observation:

    • Two patients receiving intra-arterial vasopressin for gastrointestinal hemorrhage developed SBP.
    • The peritonitis observed was polymicrobial, involving both aerobic and anaerobic bacteria.
    • This presentation differed from typical SBP, which is usually monomicrobial.

    Findings:

    • Intra-arterial vasopressin administration caused significant arterial vasoconstriction.
    • This vasoconstriction compromised the integrity of the intestinal mucosal barrier.
    • Compromised barrier integrity facilitated the transmural migration of enteric bacteria into the peritoneal cavity.

    Implications:

    • Vasopressin-induced vasoconstriction may predispose patients to polymicrobial SBP.
    • Clinicians should consider the risk of SBP in patients treated with intra-arterial vasopressin.
    • Further research is needed to elucidate the precise mechanisms and risk factors for this complication.

    More Related Videos

    The Intra-Aortic Balloon Pump06:13

    The Intra-Aortic Balloon Pump

    Published on: February 5, 2021

    27.2K
    Indocyanine Green-Guided Intraoperative Imaging to Facilitate Video-Assisted Retroperitoneal Debridement for Treating Acute Necrotizing Pancreatitis04:01

    Indocyanine Green-Guided Intraoperative Imaging to Facilitate Video-Assisted Retroperitoneal Debridement for Treating Acute Necrotizing Pancreatitis

    Published on: September 8, 2022

    2.5K

    Related Concept Videos

    Pericarditis I: Introduction01:22

    Pericarditis I: Introduction

    Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
    758
    Pericarditis III: Medical Management01:17

    Pericarditis III: Medical Management

    The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
    586
    Aneurysm IV: Nursing Management01:22

    Aneurysm IV: Nursing Management

    Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
    621
    Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

    Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

    Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
    2.1K
    Acute Pancreatitis I: Introduction01:25

    Acute Pancreatitis I: Introduction

    Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
    24