Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Causative agents for lung carcinogenesis].

S Yano1, S Sone

  • 1Third Department of Internal Medicine, University of Tokushima, School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 29, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel bioactive 31-amino acid endothelin-1 is a potent chemotactic peptide for human neutrophils and monocytes.

Journal of leukocyte biology·2001
Same author

A new quinoline derivative MS-209 reverses multidrug resistance and inhibits multiorgan metastases by P-glycoprotein-expressing human small cell lung cancer cells.

Japanese journal of cancer research : Gann·2001
Same author

Immunological circumvention of multiple organ metastases of multidrug resistant human small cell lung cancer cells by mouse-human chimeric anti-ganglioside GM2 antibody KM966.

Clinical & experimental metastasis·2001
Same author

Prevalence of emphysema in individuals who underwent screening CT for lung cancer in Nagano prefecture of Japan.

Respiration; international review of thoracic diseases·2001
Same author

[Treatment for elderly lung cancer patients by anticancer drugs and possible use of target based drugs].

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·2001
Same author

[Matrix metalloproteinase inhibitors for therapy of cancer].

Nihon rinsho. Japanese journal of clinical medicine·2001
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

Cigarette smoking is a major cause of lung cancer, damaging key genes like K-ras and p53. This review explores the molecular mechanisms behind smoking-induced lung cancer development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Context:

  • Lung cancer is a significant cause of cancer death in Japan, with rising incidence.
  • Cigarette smoking is identified as the primary carcinogen for lung cancer.
  • Environmental factors like asbestos and diet also correlate with lung cancer development.

Purpose:

  • To review recent advances in understanding the molecular mechanisms of lung cancer carcinogenesis.
  • To elucidate how cigarette smoke carcinogens initiate and promote lung cancer development.

Summary:

  • Cigarette smoke contains carcinogens that induce genetic damage in lung cancer cells.
  • Specific genetic targets include oncogenes (K-ras) and tumor suppressor genes (p53).
  • Damage to these genes is crucial for the initiation and progression of lung cancer.

Related Experiment Videos

Impact:

  • Provides insights into the molecular pathways of lung cancer.
  • Highlights the critical role of genetic damage in smoking-related lung cancer.
  • Informs future research on lung cancer prevention and treatment strategies.