Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spontaneous activity in developing turtle retinal ganglion cells: statistical analysis.

N M Grzywacz1, E Sernagor

  • 1Smith-Kettlewell Eye Research Institute, San Francisco, CA 94115-1813, USA. nmg@skivs.ski.org

Visual Neuroscience
|May 29, 2000
PubMed
Summary

Spontaneous bursts in developing turtle retinas show variable temporal properties, influenced by refractory periods and cell-to-cell propagation delays. Activity propagation between neighboring cells is inconsistent, suggesting complex excitatory processes drive retinal bursts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GABAergic control of retinal ganglion cell dendritic development.

Neuroscience·2012
Same author

iRaster: a novel information visualization tool to explore spatiotemporal patterns in multiple spike trains.

Journal of neuroscience methods·2010
Same author

Anatomical changes in the primary visual cortex of the congenitally blind Crx-/- mouse.

Neuroscience·2009
Same author

Interocular effect of intravitreal injection of 6-hydroxydopamine and dopamine on spinule formation in teleost retina.

Histology and histopathology·2002
Same author

The role of early neural activity in the maturation of turtle retinal function.

Journal of anatomy·2001
Same author

Occlusions contribute to scaling in natural images.

Vision research·2001

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Retinal Physiology

Background:

  • Spontaneous neuronal activity is crucial for neural circuit development.
  • Understanding retinal burst dynamics provides insights into early visual processing.

Purpose of the Study:

  • To analyze the temporal characteristics of spontaneous bursts in the developing turtle retina.
  • To investigate factors contributing to burst variability and propagation.

Main Methods:

  • Quantitative statistical analysis of neuronal activity.
  • Detection, clustering, and temporal property analysis of bursts.
  • Autocovariance and cross-covariance functions to assess refractoriness and cell coupling.

Main Results:

Related Experiment Videos

  • Burst properties (duration, interval, firing rate, spike count) varied significantly.
  • A positive correlation between burst duration and preceding interburst interval indicated refractoriness.
  • Cell-to-cell propagation showed a median delay of 2.3 s but with a median safety factor of 0.59.
  • Neighboring cell activity was correlated, driven by a common excitatory process with fast and slow components.

Conclusions:

  • Developing turtle retinas exhibit complex spontaneous burst activity.
  • Refractory periods and variable cell-to-cell propagation influence burst dynamics.
  • Multiple excitatory factors contribute to retinal burst excitability.